Titel
Airway inflammation in asthma : from concept to the clinic
Schrijver
Rensen, Elizabeth L.J. van
Taal
Engels
ISBN
9789090203751
Uitgever
Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University 2006 9789090203751
Prijs
€ 11,70
Bijzonderheden
160pp, Paperback / softback 160pp. in goede staat
Meer info
Keywords: Asthma
Airway inflammation
Eosinophils
CD8+ cells
Anti-IgE
Sputum
Bronchial biopsies
Airway hyperresponsiveness
PEF-variability
Allergen challengeThree aspects of airway inflammation in asthma were investigated in this thesis: proof of concept, monitoring and management.
In chapter 2 is shown that IL-5 is mainly effective in the circulation.
In chapter 3 is shown that steroids improve airway hyperresponsiveness, sputum eosinophils, and NO. The changes were not related. This suggests that these markers may provide different information when monitoring anti-inflammatory treatment in asthma.
In chapter 4 is shown that alpha-2-macroglobulin is an appropriate marker for measuring microvascular leakage in sputum. This "dual induction" model may used when testing the antiexudative effect of drugs.
Chapter 5 demonstrated that the annual decline in FEV1 is related with CD8+ cells. This suggests that inflammatory phenotypes in asthma may have prognostic relevance.
In chapter 6 is shown that PEF-variability provides information about asthma severity. Therefore, the current guidelines for the treatment of asthma can be improved by including PEF-variability.
In chapter 7 is shown that anti-IgE improves PEF, diminishes allergen responses and is paralleled by a reduction in eosinophils in biopsies and sputum and a decline in IgE+ cells. This suggests that the clinical benefits of anti-IgE in asthma may be explained by a decrease in eosinophilic inflammation and IgE bearing cells.
Airway inflammation
Eosinophils
CD8+ cells
Anti-IgE
Sputum
Bronchial biopsies
Airway hyperresponsiveness
PEF-variability
Allergen challengeThree aspects of airway inflammation in asthma were investigated in this thesis: proof of concept, monitoring and management.
In chapter 2 is shown that IL-5 is mainly effective in the circulation.
In chapter 3 is shown that steroids improve airway hyperresponsiveness, sputum eosinophils, and NO. The changes were not related. This suggests that these markers may provide different information when monitoring anti-inflammatory treatment in asthma.
In chapter 4 is shown that alpha-2-macroglobulin is an appropriate marker for measuring microvascular leakage in sputum. This "dual induction" model may used when testing the antiexudative effect of drugs.
Chapter 5 demonstrated that the annual decline in FEV1 is related with CD8+ cells. This suggests that inflammatory phenotypes in asthma may have prognostic relevance.
In chapter 6 is shown that PEF-variability provides information about asthma severity. Therefore, the current guidelines for the treatment of asthma can be improved by including PEF-variability.
In chapter 7 is shown that anti-IgE improves PEF, diminishes allergen responses and is paralleled by a reduction in eosinophils in biopsies and sputum and a decline in IgE+ cells. This suggests that the clinical benefits of anti-IgE in asthma may be explained by a decrease in eosinophilic inflammation and IgE bearing cells.
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